Prof Musa was born to the family of late Alhaji and Alhaja Imam Musa of Ile- Olomu compound, Ijaiye, Abeokuta. He attended both Nawair-ud-deen Primary and Secondary school- the former at Oke-Ijeun and the latter at Obantoko in Odeda local Government area of Ogun State. Prof Musa later attended Ogun State Polytechnic, Abeokuta (now MAUTECH) for his Higher School Certificate.

In his quest for further studies, Prof Musa proceeded to study Medicine at the University of Ibadan and obtained MBBS degree in Medicine. He had his Residency training in General Surgery at University College Hospital (UCH), Ibadan and obtained the prestigious fellowship certificate of West African College of Surgeons.

He  joined the services of Olabisi Onabanjo University/ Olabisi Onabanjo University Teaching Hospital in 1999 as a Lecturer I and an Honourary Consultant Surgeon and left for the University of Ilorin in 2009 as a Senior Lecturer. He joined the services of University of Ilorin Teaching Hospital in 2009 as an Hospital Consultant Surgeon and on the 26th September, 2011, he later joined the University as an Associate Professor of Surgery and honorary Hospital Consultant. He was elevated to the position of Professor of Surgery in 2014.

Prof Musa has Masters of Science in Anatomy and awaiting PHD in Anatomy at the Olabisi Onabanjo University.
He was appointed Chief Medical Director in 2017.

He is a member of many professional organisations among which are West African College of Surgeons, International College of Surgeons, Anatomical Society of Nigeria, International Brain Organizational, Nigerian Medical Association among others. He has Eighty (80) publication to his credit published widely in reputable Local, National and International journals.

Professor Adewale Abdul Samiu Musa has travelled widely across the globe and won many grants. He is currently working on breast cancer in both the Caucasian and black race.

He is happily married with children.